Effects of nifedipine and diltiazem on pharmacokinetics of cefpodoxime following its oral administration

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Effects of nifedipine and diltiazem on pharmacokinetics of cefpodoxime following its oral administration.

We compared the effects of nifedipine and diltiazem on the uptake of cefpodoxime proxetil (CP). The study was aimed at establishing the impact of increased mesenteric blood flow due to calcium channel blockers on passive transport. Twelve volunteers were given CP (200 mg) orally in a crossover design. The absorption, disposition, and elimination parameters of cefpodoxime were compared among the...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1996

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.40.12.2879